VITILIGO – PSORIASIS – SITEMA INMUNE

VITILIGO – PSORIASIS – SITEMA INMUNE


In this series I present you Why the immune system is important in VITILIGO and PSORIASIS diseases In 1960 sir Frank MacFarlane Burnet was awarded the Nobel Prize for his contribution to the field of immunology Burnitz clonal selection theory revolutionized our understanding of the immune system to this day Burnet’s research remains the foundation of the way we think about disease and how the body responds to it clonal selection is the central mechanism by which your body fights infection the following visualization presents clonal selection during an infection by strep throat bacteria this patient has a strep bacterial infection causing a red saw Pasi throat the tiny round strep bacteria thrive on throat tissue the bacteria are coated with hairs called M protein. to be foreign in response your body will launch an immune attack against it your lymphatic network is an important part of the immune system detecting any infections that arise in your body the M protein hairs drain into the lymphatic system around this patient’s neck the lymph node is crammed full of B cells B cells are guardians of your immune system scanning the body for foreign material arriving at the lymph node are M protein hairs from the bacteria your body contains billions of B cells each b cell is unique and is sensitive to only one kind of foreign infection by chance hairs from the bacteria this is the molecular surface of that B cell magnified ten million times its surface is covered with receptors that recognize M protein the receptors grab onto the M protein here this triggers an activation signal to travel into the cell the activated b-cell migrates and begins to replicate in a few days thousands of copies of the selected cell are made this is the central idea in Burnett’s clonal selection theory where one cell is selected out of billions of B cells and identical clones have been created from it therefore the cell is clonally selected this creates an army of B cells that mass-produce M protein antibodies and release them into the surrounding fluid the antibodies circulate in the blood and travel into tissues they bind to the M protein hairs on the strep bacteria this Flags them for destruction by the immune system. Other immune cells ingest the antibody covered bacteria, and they finally destroy the infection. In Vitiligo and Psoriasis diseases occur the same Your body attack other cells that belong to your own body by mistake, following genetical instructions.

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