Side Effects of Methotrexate

Side Effects of Methotrexate

(calm music) – Methotrexate is commonly used to treat Rheumatoid Arthritis and many other autoimmune and inflammatory conditions. In fact, it’s the first line of treatment for most people after they’re diagnosed, and it serves as the gold standard against which other
treatments are evaluated. In most people, methotrexate
does not cause any problems. We also give a prescription for a vitamin called folic acid to take every day while
you are on Methotrexate. This helps to cut down many
of the possible side effects. Sometimes, another vitamin, folinic acid, or Leucovorin, is also used. Methotrexate can infrequently
have some effects on the blood, like lowering white blood
cells and red blood cells. Methotrexate is also
metabolized in the liver. To be sure there are no
problems with your liver, blood tests will need to be done, and usually this is about once a month when you first start Methotrexate, and then when you’re on a stable dose, this usually spreads out to
about every three months. Minor side effects
might include hair loss, which is temporary and reversible, loss of appetite, nausea or vomiting, headaches, and feeling foggy or unclear, and typically that’s the day
after taking the Methotrexate. Sometimes, mouth ulcers will occur. Most of the time, these lessen as your body gets used
to the Methotrexate, but if side effects continue
or really become troublesome, check with your doctor or nurse. Get emergency help if you ever have any signs of an allergic reaction, like hives, difficulty breathing, swelling in your face, lips, tongue. That’s very, very rare though. Methotrexate can sometimes, rarely, cause an inflammation in your lungs. If you experience cough
or shortness of breath, let your doctor know. Methotrexate is not associated with an increased risk of cancer. But it’s important to recognize that people with autoimmune diseases do have a risk for cancer anyway, just because they have
an autoimmune disease. There’s some medications you should generally avoid with Methotrexate. Trimethoprim, Bactrim, or Septra acts on some of the same pathways, and Methotrexate may need to be held while you’re on those medications. There is a possible interaction with antiinflammatory drugs like Ibuprofen or Naproxen, however, many people with RA takes those on an ongoing basis and blood tests insure that
there is not a problem. (calm music)


  • Nadia Mungal says:

    Hi I am on it I don't like it but I take 4 table a week but it okay for me don't like it 🌼🌼🌼🌼🌼🌼🌼🌼🌼

  • SarahandEmma Le Moignan says:

    First line of attack.. my daughter was put on actemra infusions. They worked with steroids too, but when she comes off them, her soijra comes back hard ..flare. She starts methotrexate tomorrow night and I'm terrified for her. I've heard horror stories. Ugh.

  • Ms Magpie says:

    Have had hair loss will it grow back.

  • Ms Magpie says:

    Extremely good video,reassuring and informative .thank you.

  • Reginald Burnbridge says:

    I had hair loss nausa and it caused inflammation of my stomach very bad distension. Had to come off it.

  • akash sharma says:

    my mother is having lot of pain in her thumb on left hand, is it also one of the side effects

  • Makeda Omotola says:

    I started my first dose of 3 pills. I took it at nigh an within an hour. I felt like brain was gonna explode. I had the worst migraine ever. The morning after I almost fainted. I checked my bp it dropped pulse was 114. My heart felt like it was gonna jump out my chest while steal dealing the head ache. I felt 100% other than normal aches and pains prior to taking the methotrexate. I'm also sensitive to meds.

  • TripleJJJay says:

    This is for everyone with RA – keep up the fight. 💪 Just took my methotrexate today. Been two years since I was diagnosed, feel a lot better.

  • Kirsten Carlton says:

    It can also cause stiff lung

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