New study proves efficacy of arthritis treatment

New study proves efficacy of arthritis treatment


LAWRENCE BONASSAR: If you
have sustained arthritis that does not respond
to ibuprofen or Tylenol, one of the first-line
treatments for it are injections of
hyaluronic acid into the joint,
particularly the knee. Traditionally when the
viscosity of these formulations has been measured,
it’s been measured by placing these products
between two stainless steel plates, for example,
and measuring viscosity the same way
that you would measure the viscosity of motor oil. In our new study,
what we’ve done is looked at the measurements
that are obtained now by looking directly at how these
products lubricate cartilage. And what this tells us is that
how this molecule interacts with the cartilage
surface is a key to how it behaves in the joint. We articulate or
rub this cartilage against a very highly
polished surface. And we can do that in the
presence of any different kind of lubricant that we want. And what we discovered was there
was a very clear correlation that products that lowered
friction coefficient, that lubricated better,
those were the ones that had the greatest
clinical effects. And the ones that
didn’t lubricate so well didn’t really
change things from– compared to saline,
didn’t really have very many beneficial
effects clinically. The key points are that
we have a new method that we think predicts
clinical outcomes, that the data from
those predictions gives insights on how
these molecules are working in the joint. And what it says is
that to a large extent, its effects are mechanical. And the reason
that’s important is that it affects a
debate that’s currently active in the community about
how these products are working. And we hope that it
will inform the FDA in trying to understand how to
best regulate these devices.

1 Comment

  • Ant B says:

    Tylenol is notorious for causing Liver damage, especially when combined with alcohol, and overdoses are non uncommon…

    NSAID's, like Ibuprofen, on the other hand, have known short term risk factors but the biggest long term issue is probably Kidney failure and, if you have Arthritis, you tend to take long term, and larger, doses so if this treatment has less risk factors it would be great…

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