Manque de peau

Manque de peau


Inserm presents Lack of skin Nicolette Farman – Physiologist I am a researcher
and physiologist, and I am interested in the mechanisms
that regulate blood pressure. I am currently working on
a hormone, aldosterone, that binds to a receptor for regulating
salt reabsorption in the kidney, which is important in
regulating blood pressure. During our work we observed that the
receptor is present in the brain, heart, blood vessels, eye,
retina—and in the skin, where the role of this receptor
was completely unknown. This interested us, and led us away from our
initial interest, but that is amusing too. To move things forward, we studied mice
that overexpress this receptor in the skin, and we found that these
mice had thin, fragile skin that closely resembled the skin
abnormalities seen in people who apply corticosteroids to their skin to treat
psoriasis or atopic dermatitis, for example. We hypothesised that these very troublesome
side-effects of glucocorticoids in humans might be alleviated by
blocking the receptor. There is a tool for doing
this, spironolactone, a drug that has been used for a long
time to treat high blood pressure. We therefore treated fragments of skin
with this product, and it worked. We reduced the amount
of skin atrophy. We wanted to know if this
also worked in humans. We therefore did a clinical trial in
healthy volunteers at Bichat Hospital, a process that took ten years, but we have the result now, and
this treatment is effective. There is less skin atrophy. It is now time to begin
therapeutic development, which will probably take
about another ten years, but that is how one
develops a new treatment. Interview: Laurianne Geffroy
Directed by: JP Courbatze
Production: Ya+K Productions Music – “Planet Ndyak.412” by Etiket Zero (Chase Records)
“Départ Bonus Track” by Alt F4 (Antiblues)
“Macrohard” by Ashmex Publication: Topical mineralocorticoid receptor
blockade limits glucocorticoid-induced
epidermal atrophy in human skin. Journal of Investigative Dermatology, February 2015 Nicolette Farman
Inserm Research Director Inserm
Unit 1138 Cordeliers Research Centre

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