Klüver-Bucy syndrome – causes, symptoms, diagnosis, treatment, pathology

Klüver-Bucy syndrome – causes, symptoms, diagnosis, treatment, pathology


Learning medicine is hard work osmosis makes it easy It takes our lectures and notes to create a personalized study plan with exclusive videos practice questions and flashcards and so much more Try it free today Kluver-bucy syndrome is a neurological Affair and neurosurgeon Paul Busey, they discovered that monkeys that had bilateral temporal lobe lobectomy developed dramatic behavior changes in their memory as well as their social and sexual behaviors in Retrospect it’s not surprising that having a significant portion of the brain removed cause behavior changes in monkeys The biggest one was probably anger at Hoover and Busey for putting them through that The temporal lobe is one of the four major lobes of the brain, it has a variety of functions which are involved in sensory processing The ventral or anterior part of the temporal lobe helps process visual information like recognition of objects in faces the medial or middle portion of the temporal lobe on the other hand along with the hippocampus is responsible for formation of new memories The temporal lobe also houses the primary auditory cortex Which is needed for speech comprehension Other important structures found within the temporal lobe include the olfactory cortex Which processes the sensation of smell and the amygdala which processes emotions? The amygdala also plays a role in the reward center of the brain which motivates and reinforces behaviors that elicit positive feelings In Kluver Busey syndrome there’s a bilateral lesion of the temporal lobe the Most common cause of such a brain lesion is herpes simplex encephalitis, which is a viral infection that particularly affects the temporal lobes Other causes of kluver-bucy syndrome include trauma stroke Alzheimer’s disease and niemann-pick disease Which is a rare metabolic condition that affects various organs of the body including the brain The damage affects the amygdala which is a part of the brain that regulates emotions and reinforces behaviors related to food and sex amygdala damage also causes a diminished few response With that in mind there are three main symptoms caused by kluver-bucy syndrome hyper Faiza hyper orality and hypersexuality hyper faiza means compulsive overeating Sometimes this also presents as the consumption of inedible substances like soil and chalk a condition known as pica hyper orality is a type of compulsion where one needs to examine objects by putting it in their mouth and as the name implies hypersexuality refers to an elevated sex drive sometimes associated with various paraphilias or fetishes In addition damage to the ventral temporal lobe which is responsible for visual processing results in visual agnosia or the inability to recognize familiar objects for people Damage to the medial ventral lobe in hippocampus which both play a role in memory formation results in amnesia Diagnosis of kluver-bucy syndrome is typically made based on having the classic symptoms and is usually confirmed based on bilateral temporal lobe damage on an MRI Treatment is generally supportive and include things like assistance with daily living and occupational therapy Selective serotonin reuptake inhibitors might help treat some of the abnormal behaviors while carbamazepine might be given to specifically treat symptoms of hypersexuality alright as a quick recap Kluver-bucy syndrome is a neurological condition caused by bilateral lesions in the temporal lobe and symptoms include hyperphagia hyper orality hypersexuality docility visual agnosia and impaired memory It’s associated with herpes simplex encephalitis and can be treated with selective serotonin reuptake inhibitors and carbamazepine Thanks for watching If you’re interested in a deeper dive on this topic take a look at as Moses org where we have flashcards Questions and other awesome tools to help you learn medicine Otherwise, you can always support us by donating on patreon subscribing to our channel or following us on social media You

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