BioVendor has a long tradition in development of Antigens, Antibodies and biomarker Immunoassays. In this presentation, I will talk about antibodies produced by BioVendor The high quality antibodies are heart of a good immunoassay. Successful assay development or lot-to lot continuity of ELISA cannot be without such antibodies. We develop and produce antibodies primarily for own immunoassays so we really care about their quality. Along with a supply for our immunoassasy production we sell our products and it is no less important for us to keep our customers satisfied. We are focused on development and production of polyclonal antibodies in rabbits, sheep or goats and also on production of mouse monoclonal antibodies using hybridoma technology. Prepared antibodies can be labeled with biotin, horseraddish peroxidase, acronym ester or alkaline phosphatase What contributes to the benefits of our antibodies? We have 15 years experience on the field of Antibody development and production Every year we prepare new polyclonals and monoclonals. In present we offer about 200 of antibody products and sell them worldwide. We care about our customers and the technical support of our products is based on our experience and a good knowledge. We offer highly specific, immunoafinity purified antibodies, carefully quality tested during whole production. Many of the customers needs to further label or immobilize the antibody They certainly appreciate that our products do not contain any additives or preservatives. If you need bulk amounts, conjugates or customized antibodies, we are prepared to fill your needs. Here you can see the list of our best rated antibodies. On the following slides I will give you short introducion into them. Our most successful is rabbit polyclonal antibody against Periostin. This antibody has been a long time on the market, it is suitable for methods like immunocytochemistry, western blot and others. It’s performance is highly rated by many of our customers as you can see in number of scientific references. Periostin is well established marker. When the PTN was discovered it was thought to be involved mainly in the bone metabolisms. During the time it was revealed that periostin has an important role as a regulator of interactions between cells and extracellular matrix. Thus it is involved in many physiological and pathological processes. for example PTN is expressed during the skin wound healing as you can see on the picture of IHC staining using our antibody. There are many areas where this antibody can be used. Among others I can mention area of respiratory and alergic diseases. In recent clinical study on patients with asthma the Periostin was used as predictive marker for succesful anti-IL-13 therapy. Thus our antibody can potentially be used to identify patients with a better response to such a therapy. In another study our antibody was successfully to assess the risk of renal transplant rejection, and I could continue There are many opportunities how to take advantage of this antibody and I believe it will stay on the top of the interest also in the future. Here you can see in which research areas the antibody has been used. Monoclonal antibody against Cathepsin K has a long history on the market as well. It is suitable for the applications like immunohistochemistry, flow cytometry and others. This cysteine proteinase is involved in bone resorption and remodelation, degradation of extracellular matrix, in some types of tumors and in pulmonary tuberculosis The picture showes cathepsin K expression in melanocytic nevi, detected with our antibody. Cathepsin K is considered as a therapeutic target in osteoporosis. So the antibody could be used to diagnose effectivity of the therapy. Or this antibody can be potentialy used in identifying of certain tumors but its usage is not limited to this areas. Here you can see in which research areas the antibody has been used. Another very interesting antibody is Rabbit polyclonal anti Hepatitis Virus B protein X. Chronic and acute hepatitis B is a worldwide problem and there is a big interest in this type of antibodies. HBx is a regulatory protein and plays crucial role in pathogenesis of hepatocellular carcinoma. Roles of the HBx in hepatocarcinogenesis are sumarized in the schema. The use of this antibody is not limited to the hepatology or infectious diseases. As an example, the IHC image shows antibody performance on the kidney tissue of patient with HBV associated inflammation. Here you can see in which research areas the antibody has been used. BioVendor offers FABP4 and FABP5 ELISAs and also antibodies are in the center of the interest. FABP4 and FABP5 proteins regulates fatty acids storage and lipolysis and play roles in insulin resistance, metabolic syndrom, atherosclerosis and others. FABP4 is well known diagnostic and prognostic marker of metabolic syndrome and related disorders. Besides Metabolic syndrome, FABP5 is also involved in psoriasis, variety of tumors and is considered as a potential cardiovascular risk marker and potential therapeutic target to halt the progression of atherosclerosis. Here you can see areas where this antibody can be used and examples of antibodies performance. The COMP is a good prognostic marker in Osteoarthritis and Rheumatoid arthritis and it is proposed biomarker of breast cancer and hepatocellular carcinoma. We offer three monoclonals against COMP, well tested in different applications, The first one belongs to our bestellers and can be used in ELISA, IHC or Western blot. Adiponectin is one of the most important proteins with protective roles in energy metabolism and Type 2 Diabetes. BioVendor has a broad range of Adiponectin proteins, ELISA kits and Polyclonal Antibodies. Recently we have released two new monoclonals, which seem to be a very good Immunochistochemical reagents. In the western blot the monoclonals show different specifity. Under reduction conditions, the clone 7C11 can detect globular domain of adiponectin but not whole adiponectin as can detect the second clone. At the end a short summary: We offer well tested Polyclonal and Monoclonal antibodies with a guaranteed quality. According to your needs we will prepare bulk amounts, conjugates or customized antibodies. We have introduced here several intresting antibodies. Besides them BioVendor offers a number of others polyclonals and monoclonals, recombinant and native proteins, immunoassays and also customer services. The whole product portfolio and much more information can be found on our website. Also If you have a question, you can contact us at [email protected] Thank you for your attention.