Colon Cancer: Pathology, Symptoms, Screening, Cause and Risk Factors, Animation

Colon Cancer: Pathology, Symptoms, Screening, Cause and Risk Factors, Animation


colon cancer commonly grouped together
with colorectal cancer is cancer of the large intestine the final portion of the
digestive tract it is the most common of all gastrointestinal cancers colon
cancer usually starts from a small growth called a polyp polyps are very
common but most polyps do not become cancers polyps can be of various types
some of which are more likely to develop into malignant tumors than others early
stage colon cancer generally produces no symptoms advanced stage symptoms vary
depending on the location of the tumor and may include changes in bowel habits
that persist for weeks blood in stool abdominal pain and discomfort constant
feeling that the bowel doesn’t empty completely fatigued and unexplained
weight loss early detection is the key to prevent colon cancer because a
precancerous polyp usually takes years to develop into a malignant tumor colon
cancer can be effectively prevented with regular screening there are two major
types of screening tests stool based tests stool samples are examined for
signs of cancer such as blood and mutated DNA these tests are non-invasive
but less effective and need to be done more often visual screening such as
colonoscopy is more reliable and can be done every five or ten years colonoscopy
uses a long flexible tube equipped with a camera and light to view the entire
colon if polyps or abnormal structures are
found surgical tools are passed through the tube to remove polyps or take tissue
samples for analysis typically any polyps found in the colon are removed
during colonoscopy and examined for precancerous changes known as dysplasia
if high-grade dysplasia is detected a follow-up colonoscopy is required to
monitor the condition colorectal cancers are caused by mutations that increase
the rate of cellular division some of these mutations can be inherited from
parents examples of inherited colorectal cancers
include familial adenomatous polyposis or FAP a condition caused by mutations
in the APC gene the APC protein acts as a tumor suppressor keeping cells from
growing and dividing too fast mutations in APC result in uncontrolled
cell division causing hundreds of polyps to grow in the colon FAP patients
usually develop colon cancer by the age of 40 lynch syndrome another inherited
condition caused by changes in genes that normally help repair DNA damages a
faulty DNA repair results in increased rate of mutations patients are at high
risks of colorectal cancer as well as other types of cancers in most cases
however the mutations that lead to cancer are acquired during a person’s
life rather than being inherited the early event is usually a mutation in the
same APC gene that is responsible for FAP while FAP is a rare condition APC
mutations are very common in sporadic colorectal cancers apart from genetic
predisposition other risk factors for colon cancer include aging high red meat
and low fiber diets obesity alcohol use smoking diabetes and inflammatory
intestinal conditions such as ulcerative colitis and Crohn’s disease

2 Comments

  • Alila Medical Media says:

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  • Bethany D says:

    youtuber wil dasovich had all these symptoms

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