Biological causes of depression | Dr Janelle Sinclair explains

Biological causes of depression | Dr Janelle Sinclair explains

Hi, I’m Dr Janelle Sinclair, biochemist and
natural medicine practitioner helping you uncover the biochemical cause, discover the
natural treatment, so that you can recover from depression and anxiety. In today’s video, we’re going to quickly discuss
5 overlooked but common biological causes of depression. This includes nutrient deficiencies, hormonal
imbalances, and problems with the gut. Make sure that you stick around to the end
to find out about a symptom checklist that you can download and complete which helps
you uncover whether you have any of these biochemical imbalances. And if you’re new here, consider subscribing
and hit that bell button so that you’re notified about our weekly videos. So let’s get into it. BIOCHEMICAL IMBALANCE #1. Celiac disease. Celiac disease is a digestive disease in which
the body’s immune system reacts abnormally to gluten. Gluten is a protein found in many grains like
wheat, rye, and barley. In people who have celiac disease, the immune
system attacks and causes damage to the small intestine. The typical symptoms of celiac disease are
to do with the gut and poor digestion. These problems include Diarrhea, Constipation,
stomach pain, poor appetite, bloating and anemia or low iron or B12 levels. But more recently it’s been recognized that many
individuals have celiac but they don’t have any of the symptoms related to the gut. Instead they may suffer from other symptoms
including fatigue, depression and muscle pain. I’ve found some clients with depression or
anxiety, that have undiagnosed celiac disease. So you should check out celiac disease too. Some of these women had suffered from diarrhea
since childhood- and noone questioned it. It was thought that they had diarrhea because
of the anxiety they experienced. However, it was actually the celiac disease
which was causing both the diarrhea and the anxiety. Biochemical Imbalance number 2, which is found
in depression: Omega 3 deficiency Omega 3’s are a class of essential fatty acids. They are called essential because the body
cannot make them or store them, and therefore it is essential that you supply those valuable nutrients to your body through your diet. The brain is more than 60% fat. So it should come as no surprise that a deficiency
in fat, specifically omega 3 is involved in depression and other mental health conditions. An omega 3 deficiency is associated with neurological
conditions such as depression, ADHD, OCD, poor memory, and dementia. It’s also found in allergies, asthma, autoimmune
conditions, skin conditions such as eczema and psoriasis, as well as Cardiovascular disease. There’s physical signs that your body gives
you that you have an omega 3 deficiency too. They are oozing ear wax, joint pain, dry skin,
and hyperkeratosis (also known as “chicken skin”) on the back of the arms. I see many women during and after pregnancy
have these rough, raised bumps on the skin. So I’d like to know. Have you seen other people with chicken skin
on the backs of their arms? Or do you have it yourself? It could indicate an omega 3 deficiency, and
be the cause for mental health conditions, weight gain and skin conditions too. Let me know in the comments below. BIOCHEMICAL IMBALANCE NUMBER 3: Hypothyroidism
or Low Thyroid. Hypothyroidism is a common condition in which the
body does not produce enough thyroid hormones. The thyroid gland, is a butterfly-shaped gland
that wraps around the lower front of the neck and esophagus. The thyroid gland makes thyroid hormones,
and these hormones help control our metabolism as well as growth and development. The most well-known symptoms of low thyroid
function include Fatigue, Cold extremities, Cold intolerance, Weight gain, Constipation,
and Dry skin as well as depression. If you have any of these symptoms, or have
a thinning or loss of the outer third of your eyebrow, or you have an enlarged or swollen
neck- I’d suggest that you look further into low thyroid function. BIOCHEMICAL IMBALANCE Number 4 which is found
in depression: VITAMIN B12 DEFICIENCY Vitamin B12 is an important vitamin that plays
a key role in the nervous system. A deficiency is associated with symptoms such
as numbness or tingling in hands, legs or feet,
difficulty walking or balance problems, anemia,
a swollen tongue or inflamed tongue, difficulty thinking and reasoning,
memory loss, weakness, fatigue, depression and anxiety. The most common causes of a vitamin B12 deficiency
are gastric surgery, pernicious anemia, Coeliac disease, or Crohn’s disease. A vegan or vegetarian diet, or not eating enough red meat or eggs, is another major cause. I personally do not like vegan or vegetarian
diets especially for people that have a history or family history of mental unwellness. You see you can not get this vitamin from a vegan
or vegetarian diet, so you must take a vitamin B12 supplement. So do you think your vegan or vegetarian diet, or low meat diet, could be causing your depression? BIOCHEMICAL IMBALANCE Number 5: SIBO SIBO stands for small intestinal bacterial
overgrowth. In SIBO there is an increase in the number
or an alteration in the type of bacteria in the upper gastrointestinal tract or small intestine. Let me explain that a little bit more. It’s good and healthy for us to have bacteria
in the large intestine (the colon) – that’s where they are suppose to stay. But in SIBO, the bacteria make there way up
to the small intestine where they are not suppose to be, and they overgrow. These bacteria give off gases, such as hydrogen,
methane and hydrogen sulphide. And due to these excess gases you end up with
symptoms such as bloating, farting and burping. You can also experience diarrhea, constipation,
stomach pains and cramps. The gases from the bacteria don’t just affect
the gut they also get into the blood stream, and affect the brain and give rise to anxiety, brainfog,
low mood and fatigue. I’ve created a video on brain fog, depression and the gut, and it’s about SIBO, so watch that video for more information. Now you know about the 5 overlooked biochemical
causes of depression, and I’m sure now you’ll want to find out whether any of these play a role in your low mood or fatigue? Well I’ve created a checklist which has 29
signs that your body gives you, which can signal that you have one or more of these deficiencies or imbalances. You can download the checklist for free by
clicking the link below this video! Alternatively check out my playlist of videos
on the biological causes of depression. So I’d love to know, were there any of those
5 biochemical imbalances that stuck out to you? And is there a particular topic that you’d
like me to cover in an upcoming video? Let me know in the comment section below. And if you’ve found this video helpful, please like it, and share it with anyone that may benefit from it. And remember to hit that subscribe button
so that you keep up to date with our new weekly content. Thanks for watching and I’ll see you in the
next video.


  • Dr Janelle Sinclair says:

    Do you think you have any of these 5 biological imbalances? Which ones sound relevant to you?

  • John Green says:

    Nice video Dr.Janelle!Make video about MTHFR and pyroluria!

  • Anna Jones says:

    Great video! Both myself and my 3 children have 'chicken skin' on our arms!

  • Sam Miller says:

    I enjoyed the video. Thanks. The argument against a vegan diet because it doesn't contain b12 is a moot point. Because of modern agricultural practices, most people are eating livestock whose feed has been supplemented with b12. In other words, most of us are consuming a diet supplemented with b12, directly or indirectly. In addition, some fermented plant products such as tempeh contain b12. Surprisingly, "a survey of naturally occurring and high Vitamin B12-containing plant-derived food sources showed that nori, which is formed into a sheet and dried, is the most suitable Vitamin B12 source for vegetarians presently available. Consumption of approximately 4 g of dried purple laver (Vitamin B12content: 77.6 μg /100 g dry weight) supplies the RDA of 2.4 μg/day."  (see  )

    "For ruminant animals, like cows, they can produce B12 through bacteria in the rumen, but they need cobalt in their diet to do so. Since lots of soil is depleted with cobalt, these cows need a cobalt supplement. Most cattle are not grass-fed, but grain-fed, so their cobalt-supplemented feed may not provide them a significant amount of B12, in which case they need a B12 supplement.
    Note that pigs and chickens are not ruminants, so they get B12 from their diet. Since their feed consists of grains, soy, and other plant foods (which are currently not a significant source of B12 due to modern agriculture), they need supplementation." See sources from

    In terms of getting therapeutic doses of epa/dha for depression, supplementation is likely required since deep-water fish is contaminated and so consumption has to be limited. Plant-sourced dha/epa algae oil is superior to fish oil in terms of sustainability, low heavy metal toxicity, and minimal rancidity. Also, from what I read, one can significantly increase epa/dha levels from reducing the consumption of omega-6's which compete for the same enzymes that convert omega 3 alpha-linolenic acid into epa/dha. Ahiflower oil contains high levels of the omega-3 Stearidonic acid (SDA), sometimes called moroctic acid, biosynthesized from alpha-linolenic acid by the enzyme delta-6-desaturase. SDA bypasses the limiting delta-6-desaturase enxyme allowing much higher epa levels than flax oil. However, the advantage of fish-oil to either algae or ahiflower is that it costs less. My point is that for those suffering from psychiatric conditions, the amount of omega 3 available in a few servings of fish a week is unlikely to reach therapeutic dose used in most studies. So regardless if one is vegan or not, supplementation is still likely required to treat depression and anxiety.

  • Sage k says:

    Thanks for the info 👍🏻

  • Isabella Polanco says:

    This is sooooo good!!

Leave a Reply

Your email address will not be published. Required fields are marked *